Expression level and correlation of IL-23 and MMP-9 in esophageal squamous cell carcinomas

VernacularTitle:食管鳞癌患者血清 IL-23和 MMP-9的相关性及其临床意义
Author: Song HU ; Jianji GUO ; Tao LIU ; Mingwu CHEN ; Lei XIAN ; Yongyong WANG ; Qian ZHOU ; Xiang TAN
Publication Type:Journal Article
Keywords: Esophageal squamous cell carcinomas; IL-23; MMP-9; Invasion and metastasis; Correlation
From: The Journal of Practical Medicine 2014;(18):2905-2907
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of the serum level of IL-23 and MMP-9 with the clinicopathologic features in patients with esophageal squamous cell carcinoma (ESCC). Methods 48 pathologically confirmed ESCC patients and 30 Endoscopic biopsy of benign were included in this study. The serum levels of IL-23 and MMP-9 were examined by enzyme-linked immunosorbent assay (ELISA). Results Serum IL-23 level in patients with ESCC was significantly higher than that in controls (t = 26.66, 16.89, P<0.05). Furthermore, Pearson′s correlation analysis revealed that serum IL-23 was positively correlated with the serum MMP-9 level in ESCC patients (r = 0.790, P < 0.05). Statistical analysis showed that enhanced serum IL-23 significantly correlated with the degree of differentiation and lymph node metastasis. Conclusion Overexpression of IL-23 may involve in the occurrence and development of ESCC. IL-23 may contribute to tumorinvasion and metastasis by stimulating the expression of MMP-9.