Effects of Blood Nourishing and Wind Expel Formulae on Learning and Memory Capabilities of Rats with Tic Disorders
10.3969/j.issn.1005-5304.2014.11.022
- VernacularTitle:养血祛风方对抽动障碍大鼠学习记忆能力的影响
- Author:
Liqun WU
;
Lina WEI
;
Yingmin YIN
;
Haipeng CHEN
- Publication Type:Journal Article
- Keywords:
blood nourishing and wind expel formulae;
tic disorders;
learning and memory capabilities;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(11):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of blood nourishing and wind expel formulae on learning and memory capabilities of rats with tic disorders. Methods Intradialytic Parenteral Nutrition peritoneal injection was used to establish the rat model of tic disorders. The successful test subjects were categorized into 5 different groups, namely the model group, the Chinese medicine groups (low dosage, medium dosage and high dosage) and the western medicine group. The test groups were each given gastric perfusion of the related medicine, whereas the control and model groups were each given equal amounts of saline solution continuously for 8 weeks. Open field test and water maze test were carried out in the 1st, 4th and 8th weeks to evalute the learning and memory capabilities. Results In comparison with the control group, the model group showed obvious increase in movement across grid and decrease in vertical locomotion. Statistical significance was obtained showing an increase in vertical locomotion in the treatment groups compared with the model group. In the Chinese medicine groups, the medium and high dosage groups exhibited shorter escape latency and increased exploratory behavior (P<0.05) in the 4th and 8th weeks. Conclusion Among the blood nourishing and wind expel formula, the medium and high dosage showed ameliorating effects on the memory and learning capabilities of rats with tic disorders.
