Comparison of Contents of Forsythoside A and Forsythin in Fructus Forsythia and Its Dispensing Granule
10.3969/j.issn.1005-5304.2014.11.027
- VernacularTitle:连翘药材及其配方颗粒中连翘酯苷A和连翘苷含量比较
- Author:
Jiangping ZHENG
;
Zhengde YE
;
Jun LIANG
;
Liangyong HUANG
- Publication Type:Journal Article
- Keywords:
Fructus Forsythia;
dispensing granule;
forsythoside A;
forsythin;
content determination
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(11):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the contents of forsythoside A and forsythin in Fructus Forsythia and its dispensing granule. Methods HPLC-gradient elution method was used with SunFire C18 column (4.6 mm×250 mm, 5μm), mobile phase A of acetonitrile and B of acetic acid, flow rate of 1.0 mL/min, detection wavelength of 277 nm, and column temperature at 30 ℃. HPLC was used to determine the contents of forsythoside A and forsythin in Fructus Forsythia and its dispensing granule, and compare the difference between the two contents. Results The content of forsythoside A in dispensing granule was less than that of raw material of Fructus Forsythia, and the concentration of the major components in the commercial Lianqiao Granule were not equivalent to that in the decoction of Fructus Forsythia. The content of forsythin in dispensing granule was equivalent with that of raw material of Fructus Forsythia. Conclusion The original formula granule production process needs to be improved, and the standardized criteria for the quality control and reasonable quality standard of granule should be established.
