The effects of the compound lavender ointment on experimental guinea pigs scald、anti-inflammation and analgesia
10.3969/j.issn.1671.7856.2014.009.007
- VernacularTitle:复方薰衣草油膏治疗实验性豚鼠烫伤、抗炎及镇痛的效果观察
- Author:
Xin LUO
;
Yan SUN
;
Xuewei YONG
;
Yingfang GUO
;
Linlin LI
;
Qun ZHANG
- Publication Type:Journal Article
- Keywords:
Compound lavender ointment;
Scald;
Wound;
Wound healing
- From:
Chinese Journal of Comparative Medicine
2014;(9):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the main pharmacodynamics effect of compound lavender ointment on the scald, anti-inflammation and analgesia.Methods Sixty guinea pigs were divided into normal groups,model groups( superficialⅡ°scalding models) ,compound lavender ointment high,median,low dose groups,and jing wan hong ointment groups,then observation of the wounds and healing was made and recorded.Histopathological examination was made to examine the wounds,and ELISA to analyze serum TNF-α、IL-6、IL-8.Xylene ear swelling model and writhing test were used to observe the analgesic and anti-inflammatory effects of the compound lavender ointment.Results Compound lavender ointment can relieve the wounds swelling and exudation,which may be related to the decrease of proinflammatory cytokines(P <0.01), and promote the wound healing significantly( P <0.01) ,that the side-effects were not observed.High dose of compound lavender ointment can inhibit ear swelling and have certain analgesia with the writhing tests.Conclusion Compound lavender ointment have the promoting wound healing,anti-infectious and antalgic effects on the scald.
