Relationship between TCM Constitutional Types and TGF-β1 Levels in Serum of Patients with Knee Osteoarthritis
10.3969/j.issn.1005-5304.2014.10.009
- VernacularTitle:膝关节骨性关节炎患者中医体质类型与血清转化生长因子-β1表达水平的相关性
- Author:
Mingwang ZHOU
;
Xiaoping WANG
;
Shenghua LI
;
Tiefeng GUO
;
Fengqi SUN
;
Huanxi MU
- Publication Type:Journal Article
- Keywords:
TCM constitution type;
knee osteoarthritis;
TGF-β1;
qi deficiency constitution
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(10):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between TCM constitutional types and the levels of transforming growth factor beta 1 (TGF-β1) of patients with knee osteoarthritis (KOA). Methods A total of 161 patients with KOA as a case group filled out questionnaires about 9 TCM constitution types, and 50 cases of unrelated healthy volunteers were selected randomly as control group. The serum samples of two groups were collected. The levels of TGF-β1 were detected and compared by double antibody sandwich ELISA. Results Compared with the control group, the level of TGF-β1 in the case group decreased, with statistical significance (P<0.05). Compared with the control group, the levels of TGF-β1 significantly decreased in the case group of qi deficiency type, with statistical significance (P<0.05). There were no types of special intrinsic and blood stasis. Compared with the control group, the levels of TGF-β1 in the other six types of patients with KOA had no statistical significance (P>0.05). Conclusion The incidence of KOA with qi deficiency type may be related to the decrease of TGF-β1 level. The decreasing level of TGF-β1 may be one of the mechanisms of molecular biology that qi deficiency was linked to KOA.
