A review of vascular regeneration in the invasive growth process of Echinococcus multilocularis

VernacularTitle:血管新生在肝泡球蚴浸润性生长中的作用
Author: Tong LI ; Shijie ZHANG
Publication Type:Journal Article
Keywords: alveolar echinococcosis; vascular; invasive growth; VEGF; CD34
From: Chinese Journal of Zoonoses 2014;(10):1071-1074
CountryChina
Language:Chinese
Abstract: Alveolar echinococcosis (AE) is a potentially fatal zoonosis caused by Echinococcus multilocularis (E .m) , primary located in the liver and showed malignant invasion .AE can develop to the lungs and brain metastases .Operation treat-ment and medication therapeutic efficacy show poor effect .The mechanism of AE invasive growth and metastasis is unclear . Angiogenesis is a highly regulated behavior in normal tissues .Abnormal angiogenesis is one of the key signs of malignant tumor ,and VEGF is one of the key mediators of angiogenesis .Numerous studies have shown that VEGF and CD34 plays an important role in the formation of tumor angiogenesis and invasive growth process .This article discussed the role of angiogene-sis in AE aggressive ,aimed to provide a new way for the clinic conservative treatment for patients with advanced stage ,preven-ting recurrence after operation ,and adjunctive therapy of operation and drug .