Humanized mouse models for liver disease research:a review
10.3969/j.issn.1005-4847.2014.05.021
- VernacularTitle:用于肝脏疾病研究的人源化小鼠模型概述
- Author:
Xiaonan REN
;
Xiaohui ZHOU
- Publication Type:Journal Article
- Keywords:
Humanized mice;
Liver disease;
Human-mouse liver chimeric model
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(5):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Liver diseases post great threats to human public health globally.Lacking of appropriate small animal models largely impeded the translational studies on human liver diseases, especially on viral hepatitis and related cirrhosis, hepatocellular carcinoma, etc.By human hepatocyte transplantation, the liver-humanized mice have significantly contribu-ted to the researches of human liver diseases.This review summarizes the currently widely used and representative human-ized mouse models, including uPA, FAH, TK-NOG, AFC8 mice and their applications in studies of human liver diseases.
