Advances in research on experimental animal models of HCV infection
10.3969/j.issn.1005-4847.2014.05.020
- VernacularTitle:丙型肝炎病毒感染实验动物模型的研究进展
- Author:
Chenchen JIANG
;
Zonggen PENG
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Naturally infected animal models;
Surrogate animal models;
Rodents
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(5):87-94
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus ( HCV) is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcino-ma in humans.Due to the lack of suitable experimental animal models for HCV infection, the development of more effective treatment of HCV infection and vaccines has been delayed.Chimpanzee is the best experimental animal model for the re-search of hepatitis C virus ( HCV) infection.However, because of its limited in resource, expensive in breeding, and difference in clinical symptoms, thus developing new experimental animal models for HCV-related basic and applied re-search is imminent.In recent years, as a surrogate animal model, the development of rodent model and other models has been achieved a lot of progress.Using such as genetically modified experimental techniques, those surrogate animals were infected with HCV in vivo and were successfully applied to research in several areas.In this review, we will focus on the a-chieved progress in naturally infected animal model and transgenic surrogate experimental models, and their advantage and limitation in usage in study on the pathogenetic mechanism of infection, drug evaluation and development of vaccines, and will also discuss the future direction of development of experimental animal models for research of infection with HCV.
