Safety of modified sputum induction in moderate-to-very severe COPD during exacerbation
10.3969/j.issn.1006-5725.2014.17.019
- VernacularTitle:改良诱导痰技术在中重度、极重度慢性阻塞性肺疾病急性加重期中应用的安全性分析
- Author:
Liping WEI
;
Shanshan KANG
;
Sheng HE
;
Min LIN
;
Tianhua ZHU
;
Weiqiang LIANG
;
Fang LI
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Sputum induction;
Acute exacerbations;
Safety;
Respiratory failure
- From:
The Journal of Practical Medicine
2014;(17):2751-2753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of modified sputum induction in moderate to very severe COPD during exacerbation. Methods Ninety patients with moderate, severe or very severe COPD during exacerbation (27 with type Ⅰ and Ⅱ respiratory failure,18 with coronary heart disease, 38 with tachycardia) were chosen as research subjects. All the patients underwent induced sputum. During induction , all patients were given electrocardiographic monitoring and pulmonary function check every 5 minutes and FEV1, HR, SpO2 in the process of testing were recorded. Results Ninety patients underwent 224 sputum inductions progress, 222 were safety. Qualified sputum samples were collected for 216 times, sputum induction was successful in 96.43% of occasions. Heart rate rising and SpO2 reducing during sputum induction mainly occurred in the beginning 5 minutes, FEV1 did not change in the whole process. Conclusion Modified sputum induction can be safe through closely monitoring in patients with moderate-to-very severe COPD with exacerbation, even with type Ⅰ or typeⅡ respiratory failure. But the risk of sputum induction will increase if patients with coronary heart disease and tachyarrhythmia, especially within beginning 5 minutes of sputum induction.
