Effect of motivation of EPCs by G-CSF on cardiac function in patients with myocardial infarction
10.3969/j.issn.1006-5725.2014.17.022
- VernacularTitle:粒细胞集落刺激因子动员内皮祖细胞对心肌梗死患者心功能的影响
- Author:
Shaolan LIANG
;
Zuoyi DU
;
Zicheng LI
;
Wen JIN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Granulocyte colony-stimulating factor;
Endothelial progenitor cells
- From:
The Journal of Practical Medicine
2014;(17):2759-2761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of motivation of endothelial progenitor cells (EPCs) by granulocyte colony-stimulating factor (G-CSF) on cardiac function in patients with myocardial infarction (MI). Methods Eighty MI patients were sellectedand then were divided into a conventional treatment group (n = 40) and a EPC motivation group (n = 40). EPCs were detected by flow cytometry. Results The rate of EPCs was increased from (0.11 ± 0.04)% in the baseline to (5.32 ± 1.06)% (P < 0.05). Before treatment, 6MWT, LVEF, and LVEDD did not differ significantly between the conventional treatment group and the EPC motivation group (P > 0.05); after treatment, 6MWT, LVEF, and LVEDD were significantly increased in both groups (P < 0.05 and P < 0.01). However, 6MWT, LVEF, and LVEDD were higher in the EPC motivation group than in the conventional treatment group (P <0.05). The clinical effectiveness rate was higher in the EPC motivation group than in the conventional treatment group (90.0% vs. 75.0%, P < 0.05). There was no significant difference between the two groups in adverse reactions (7.5%vs. 10.0%, P > 0.05). Conclusions G-CSF can markedly motivate EPCs, which is beneficial for improvement of cardiac function in MI patients.
