Clinical analysis of two different chemotherapy regimens for concurrent chemoradiotherapy in advanced cervical cancer for Uyghur women
10.3969/j.issn.1006-5725.2014.18.021
- VernacularTitle:TP与 PVB 两种同步放化疗方案在维吾尔族中晚期宫颈癌的近期疗效比较
- Author:
Lufang WANG
;
Nana HAN
;
Mingfang RU
;
Kaijiang LIU
- Publication Type:Journal Article
- Keywords:
Chemoradiation;
Cervical tumor;
Uygur;
Advanced;
Antineoplastic protocols
- From:
The Journal of Practical Medicine
2014;(18):2928-2930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare theshort-term efficacy and safety between TP and PVB scheme chemoradiation for advanced cervical cancer. Methods Between January 2012 and January 2014, 187 Xinjiang uygur patients with advanced cervical cancer (stageⅡb to Ⅳa) who received concurrent chemoradiotherapy in Xinjiang medical university affiliated tumor hospital were analyzed. A1l cases were divided into two groups receiving radiotherapy concomitant (n = 104), PVB group (n = 83). Theshort-term efficacy and toxicity was evaluated four weeks aftertreatment. Results For squamous cell carcinomas, the response rates were 85.9% and 73.5% in TP and PVB group respectively (P > 0.05). For Non-squamous cell carcinomas (adenocarcinoma and adenosquamous), the response rates were 75.7% and 40% in TP and PVB group respectively (P < 0.05). B one marrow suppression, neurotoxicity, gastrointestinal reactionwere significant different between two groups (P <0.05). Liver and kidney functiondisorder, blood cellsreduction, and radiation damagewere not significantly different (P > 0.05). Conclusions For cervical squamous cell carcinomas, theshort-term efficacy of two chemotherapy regimens is similar while forNon-squamous cell carcinomas, TP regimengroup is superior toBone marrow suppression and neurotoxicity in TP regimengroup is significantly higher than PVB group (P < 0.05), while gastrointestinal adverse reaction lower than PVBgroup.
