A meta-analysis of effect and safety of high-dose ambroxol in treatment of acute exacerbration of chronic obstructive pulmonary disease
10.3969/j.issn.1006-5725.2014.18.041
- VernacularTitle:大剂量氨溴索治疗慢性阻塞性肺疾病急性加重期疗效与安全性的 Meta 分析
- Author:
Chunli REN
;
Jun RUAN
;
Lili MIAO
- Publication Type:Journal Article
- Keywords:
Ambroxol / high-dose of ambroxol;
Chronic obstructive pulmonary disease;
Meta-analysis
- From:
The Journal of Practical Medicine
2014;(18):2986-2990
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of high-dose Ambroxol in treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Retrieved from PubMed, EMbase, Cochrane Library, CNKI, VIP and WanFang databases by computer, randomized controlled trials (RCTs) about high-dose of Ambroxol in treatment of AECOPD were included. According to the inclusive and exclusive criteria, literatures and data were independently screened and extracted by two researchers, and the quality of the studies were assessed, Meta-analysis was conducted by RevMan 5.2 software. Results A total of 7 RCTs were included, involving 534 patients. Meta-analysis showed that experiment group can obviously improve the overall effective rate [OR = 4.11, 95%CI (2.31, 2.31), P < 0.000 01), shorten hospital stays(OR = 3.60, 95% CI (4.66, 2.55), P < 0.00001), compared with the control group was statistically difference, and no obvious adverse reactions. Conclusion High-dose of Ambroxol could improve AECOPD overall effective rate, shorten hospital stays, improve pulmonary function and blood gas analysis, and no serious adverse reactions, be worth clinical promote using.
