The comparative study of neurological function score and subgroups analysis for rats at different ages after CPR modeling
10.3969/j.issn.1671.7856.2014.009.012
- VernacularTitle:2月龄和4月龄大鼠制备心肺复苏模型后神经功能评价及亚组评分的比较
- Author:
Xin TIAN
;
Jing WANG
;
Xinchen ZHAO
;
Xiaochao ZHOU
;
Feng YAN
;
Jingyu HE
;
Deyu GUO
- Publication Type:Journal Article
- Keywords:
Cardiac arrest;
CPR;
Neurologic function;
Hypoperfusion;
Cerebrum injury;
Rat
- From:
Chinese Journal of Comparative Medicine
2014;(9):53-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to select suitable ages of rats for the CPR ( cardiopulmonary resuscitation) animal model.The neurological function score and subgroups analysis are evaluated in 2 month old and 4 month old animal groups.Methods Based on the evaluation of physiological indexes including ECG, blood pressure and neurological function defect score ( NDS) and subgroup analysis, the stability of CPR rats model was compared between 2 month old and 4 month old animal groups.Results The results showed that, the model rate of the ventricular fibrillation was induced by electrical stimulation , the 4 month old group was 87.5%, significantly higher than the 2 month old group, however, there was no significant difference between the two groups in the mortality rate;For the changes of blood pressure during the process of CA( cardiac arrest) induced by electrical stimulation, the 4 month old group was significantly lower than the 2 month old group (P <0.01); for the NDS at each time point after CPR, there was no significant difference between the two groups; however, the NDS subgroup analysis at different time points showed that there were different degrees of differences between the two age groups ( P <0.05) .Comparing with the 2 month old group, the 4 month old group had a stable process during the animal model preparation, had an obvious cerebral blood hypoperfusion phenomenon and aggravation of brain injury after CPR.Conclusion The 4 month old rats are more suitable for preparation of CPR animal mode , the model rate is high, the brain injury aggravate.It is more suitable evaluation for basic research and treatment of CPR.
