Resistant mechanism about rapamycin and solution
10.3760/cma.j.issn.1673-422X.2014.10.007
- VernacularTitle:雷帕霉素耐药机制及其逆转途径
- Author:
Kejun CHEN
;
Shuqing LYU
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Drug resistance;
mammalian target of rapamycin
- From:
Journal of International Oncology
2014;41(10):740-743
- CountryChina
- Language:Chinese
-
Abstract:
mTOR signaling pathway is closely related to cell proliferation,cell cycle and other pathological processes about tumor.Rapamycin plays an anti-tumor effect through inhibiting mTOR,but it prone to drug resistance,which leads to limited clinical application.Its resistant mechanism is related with the activation of PI3K-Akt,which is regulated with negative feedback.Dual inhibitors of related proteins of mTOR pathway are expected to reverse the drug resistance.
