Therapeutic effect of urapidil and nitroglycerin in elderly female non-valvular heart failure patients
10.3969/j.issn.1009-0126.2014.10.007
- VernacularTitle:乌拉地尔和硝酸甘油治疗老年女性非瓣膜性心力衰竭患者的疗效观察
- Author:
Wei YANG
;
Qi HUA
- Publication Type:Journal Article
- Keywords:
heart failure;
nitroglycerin;
shock,cardiogenic;
hypertension;
diabetes mellitus,type 2
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2014;(10):1032-1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess whether urapidil (anα1 receptor blocker)is more effective than ni-troglycerin in treatment of non-valvular heart failure accompanying hypertension and diabetes mellitus (DM ) in elderly female patients .Methods Fourty-six elderly female patients with non-valvular heart failure accompanying hypertension and DM were randomly divided into urapidil treatment group (n= 24) and nitroglycerin treatment group (n= 22) .Patients in urapidil treat-ment group were treated with urapidil (50 -300 μg/min) and those in nitroglycerin treatment group were treated with nitroglycerin (5 -20 μg/min) for 48 -140 h according to their blood pressure (BP) and cardiac function .Their BP ,HR ,and metabolic activity were observed before and on days 1 ,2 ,3 and 7 after treatment .Results The effect of urapidil was significantly lower than that of nitroglycerin on SBP on day 7 after treatment (P<0 .05) .The serum NT-proBNP level was significantly lower in nitroglycerin treatment group than in control group (P<0 .01) . Conclusion The effect of urapidil is better than that of nitroglycerin on reducing and stabilizing SBP ,attenuating cardiac afterload ,and improving cardiac function in elderly female patients .Ura-pidil can thus be used as one of the first choiced drugs in treatment of elderly female patients with non-valvular heart failure accompanying hypertension and DM .
