Expression and clinical significance of transcription factor special protein 1 in colorectal cancer

VernacularTitle:转录因子特化蛋白1在大肠癌组织中的表达及意义
Author: Jinhua MIAO ; Yeping DU ; Lili YIN ; Chunmei WU ; Liping XU
Publication Type:Journal Article
Keywords: transcription factor special protein 1; colon cancer; lymph node metastasis
From: International Journal of Laboratory Medicine 2014;(19):2597-2598
CountryChina
Language:Chinese
Abstract: Objective To study the expression of transcription factor special protein 1(Sp1) in colorectal cancer tissues and the relationship with the biological behavior .Methods The Sp1 mRNA expressions of 60 colon cancer tissues and their corresponding normal tissues were detected by real-time PCR ,and the level of target gene was calculated by ΔΔCT method .The relationships be-tween the expression of Sp1 mRNA and the different clinical features and pathological characters were determined .Results Com-pared with the matched normal tissues ,Sp1 mRNA was significantly up-regulated in the colon cancer tissues(P<0 .01) .Sp1 mRNA positive expression rate in colon cancer tissues had no significant different with sex ,age and tumors area(P>0 .05) ,but had signifi-cant different with histological grade ,Duke′s stages and lymph node metastasis(P<0 .05) .Conclusion Sp1 plays an important role in the process of occurrence and development in colon cancer .