Study of correlation between the levels of serum immunoglobulin core fucosylation and humoral immune parameters in patients with schizophrenia
10.3969/j.issn.1673-4130.2014.19.023
- VernacularTitle:精神分裂症患者血清免疫球蛋白核心岩藻糖基化水平与体液免疫指标的相关性研究
- Author:
Jing GUO
;
Jinyun QIU
;
Fangbo FENG
- Publication Type:Journal Article
- Keywords:
schizophrenia;
humoral immunity;
immunoglobulin core fucosylation
- From:
International Journal of Laboratory Medicine
2014;(19):2626-2627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the levels of serum immunoglobulin core fucosylation and humoral immune parameters in patients with schizophrenia and its immunological significance .Methods The levels of serum lens culinaris agglutinin(LCA)-IgM ,LCA-IgG ,LCA-IgA ,IgM ,IgG ,IgA ,circular immune complex(CIC) in patients with schizophrenia(n= 46) and health people(n=47) were determined .Their correlations were investigated by linear regression analysis .Results There was a positive correlation between the LCA-IgA and IgG in healthy people(r=0 .311 7 ,P<0 .05) .However ,there was a negative correla-tion between LCA-IgG and IgA in patients with schizophrenia(r=0 .323 6 ,P<0 .05) .In addition ,there were positive correlations between LCA-IgM ,LCA-IgG ,LCA-IgA and CIC(r=0 .354 8 ,r=0 .189 8 ,r=0 .479 7 ,P<0 .05) .Conclusion Increased fucosyla-tion levels of immunoglobulin were detected in patients with schizophrenia ,which may play important roles in immunological inju-ries of central nervous system in schizophrenia .
