Clinical detecting application of TK1 in the diagnosis of common malignant tumors
10.3969/j.issn.1673-4130.2014.19.028
- VernacularTitle:T K1检测对常见恶性肿瘤诊断的临床应用
- Author:
Zhijian ZHANG
;
Yanping ZHENG
;
Yuanfeng LIN
;
Xuqiao MEI
- Publication Type:Journal Article
- Keywords:
serum thymidine kinase 1;
tumor;
tumor marker
- From:
International Journal of Laboratory Medicine
2014;(19):2636-2637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical application of thymidine kinase 1(TK1) in diagnosis of common malignant tumors . Methods The serum TK1 levels of 444 cancer patients and 161 healthy individual(control group) were tested by western blot-en-hanced chemiluminescence assay .Results Compared with control group ,the levels of TK1 in patients with lung cancer ,gastrointes-tinal cancer or breast cancer were significantly higher(P<0 .05) .The positive rates of TK1 in lung cancer ,esophageal cancer ,colon cancer ,colorectal cancer ,breast cancer ,cervical cancer and ovarian cancer were respectively 52 .0% ,59 .6% ,62 .9% ,60 .0% , 62 .1% ,32 .3% ,21 .4% and 11 .0% .Compared with control group(the positive rate of TK1 was 0 .0% ) ,the positive rate of TK1 in lung cancer ,gastrointestinal cancer or breast cancer were significantly higher(P<0 .01) .Conclusion The test of serum TK1 is a valuable marker in common malignant tumor auxiliary diagnosis .
