Clinical Analysis of Hydroxychloroquine Combined with Low-Molecular-Weight Heparin and Glucocorticoids in Treatment of Pregnant Women with Antiphospholipid Syndrome
10.3969/j.issn.0253-9896.2014.10.018
- VernacularTitle:羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征效果分析
- Author:
Li QI
;
Xiaoli ZHANG
;
Xiaofei WANG
- Publication Type:Journal Article
- Keywords:
antiphospholipid syndrome;
pregnancy;
hydroxychloroquine;
heparin,low-molecular-weight;
glucocorticoids
- From:
Tianjin Medical Journal
2014;(10):1023-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and efficacy of hydroxychloroquine plus low-molecular-weight hep-arin and glucocorticoids in pregnant women with antiphospholipid syndrome (APS). Methods Clinical data of 12 pregnant women with APS were retrospectively analyzed. Eight patients were APS secondary to connective tissue disease while four were primary APS. Hydroxychloroquine plus low-molecular-weight heparin was employed for the treatment of all the pa-tients,among some of whom undergone combined glucocorticoids therapy. Results All patients underwent a successful de-livery with no abnormalities and are with normal Apgar scores of the babies. No compliations were developed during a follow up of 2-15 months. Conclusion Hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids is safe and effective in treatment of pregnant women with APS, but its clinical value needs further investigate.
