Redox Regulation of Cardiac Na and Ca Handling Protein
10.3969/j.issn.0253-9896.2014.10.024
- VernacularTitle:心脏氧化还原系统对钠钙处理蛋白的调控机制
- Author:
Yangong LIU
;
Gang LIU
;
Pu WANG
;
Mingqi ZHENG
- Publication Type:Journal Article
- Keywords:
oxidation stress;
Na+and Ca2+handling;
reactive oxygen species;
redox system;
arrhythmias
- From:
Tianjin Medical Journal
2014;(10):1043-1047
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac contractile dysfunction and arrhythmic genesis are resulted from disturbed intracellular Na+and Ca2+ handling under condition of oxidation stress. Stress-induced intracellular signaling regulated mechanisms in which many activated stress kinases, such as cAMP-dependent protein kinase A, protein kinase C , Ca/calmodulin-dependent pro-tein kinaseⅡand classical pathways, are known to be involved. However, it is becoming increasingly evident that reactive oxygen species may directly oxidize these kinases, Na+and Ca2+channel protein and transporters, which lead to changing of intracellular Na+and Ca2+accumulation, and to trigger of arrhythmias.
