Comparison of glucose and lipid metabolism in two types of Parkinson’ s disease rat models
10.3969/j.issn.0529-1356.2014.05.004
- VernacularTitle:两种帕金森病大鼠糖脂代谢模型的比较
- Author:
Xiangzhi MENG
;
Ruipan ZHENG
;
Ying ZHANG
;
Mingliang QIAO
;
Peng JING
;
Yan GAO
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Glucose and lipid metabolism;
6-hydroxydopamine;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
2014;(5):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To select an ideal Parkinson ’ s disease ( PD) animal model with metabolic abnormalities for subsequent experimental studies .Methods A total of 62 Sprague-Dawley male rats were randomly divided into four groups:damaged medial forebrain bundle ( MFB) model group, damaged medial forebrain bundle ( MFB) sham group, damaged Striatum model group and damaged Striatum sham group .After detecting the rotation experiment , successful model rats of two groups were selected to detect the changes of food intake , body weight , blood glucose and intra-abdominal adipose tissue.Results It was easier to produce a PD model by destroying MFB than striatum .Compared with sham-operated rats, MFB model rats showed significant abnormality both in reduction of body weight [(218.1 ±13.99) g vs (252.7 ±10.1)g, P<0.05] and high blood glucose appeared at 15min and 30min after introperitoneal glucose tolerance test ( IPGTT) .Their perirenal white adipose tissue was significantly reduced ( both left and right side ) .Striatum model rats only appeared decreased food intake [(13.95 ±0.25)g vs (20.23 ±0.86)g, P<0.001] and impaired glucose regulation at 15min, 30min and 60min after IPGTT.Their body weight and adipose tissue did not change significantly .Conclusion No matter in the success rate or metabolism-related indicators , MFB damaged rat model of PD is more suitable to study PD patients with abnormal lipid metabolism compared with Striatum rat model .
