The effects of scutellarin on Bcl-2 and Bax expression in human tongue squamous carcinoma Tca-8 1 1 3 cells
10.3969/j.issn.1001-3733.2014.05.014
- VernacularTitle:野黄芩苷对人舌鳞癌Tca8113细胞Bcl-2、Bax表达的影响
- Author:
Zhihua GE
;
Ying ZHANG
;
Junmei LI
;
Ning YANG
;
Haizhong YU
;
Jianing YANG
- Publication Type:Journal Article
- Keywords:
Scutellarin;
Tca81 13 cells;
Bcl-2;
Bax
- From:
Journal of Practical Stomatology
2014;(5):649-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of scutellarin on Bcl-2 and Bax expression in human tongue squamous carcinoma Tca-8113 cell.Methods:Tca8113 cells were treated with 80,120 and 160μg/ml scutellarin for 48 h respectively.Immunocytochem-istry method and RT-PCR were applied to observe the expression of Bcl-2 and Bax protein and mRNA in the cells.Results:With the increase of scutellarin concentration,Bcl-2 protein and mRNA decreased(P<0.05),Bax protein and mRNA increased(P<0.05). Conclusion:Scutellarin may downregulate Bcl-2 expression and upregulate Bax expression in Tca-8113 cells.
