The clinical significance of EGFR,PCNA,LN and type IV collagen expression in salivary adenoid cystic carcinoma
10.3969/j.issn.1001-3733.2014.05.018
- VernacularTitle:EGFR、PCNA、LN、IV型胶原在SACC中的表达及临床意义
- Author:
Guixia DU
;
Fan ZHANG
;
Xiuying HUO
;
Liheng LI
;
Ruiping LI
;
Bo LIU
;
Jiuhong ZHANG
;
Rui BAI
;
Xiufang ZHAO
- Publication Type:Journal Article
- Keywords:
SACC;
EGFR;
PCNA;
LN;
Type IV collagen;
Fluorescence in situ hybridization;
Immunohisto-chemistry
- From:
Journal of Practical Stomatology
2014;(5):667-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of epidermal growth factor receptor(EGFR),proliferating cell nuclear antigen(PCNA),laminin(LN)and type IV collagen expression in salivary adenoid cystic carcinoma(SACC).Methods:EGFR gene in 78 cases of SACC with complete clinical data was detected by fluorescence in situ hybridization(FISH)technique,the expression of EGFR,PCNA,LN and type IV collagen protein was detected by immunohistochemistry technique(IHC),their correlation with the clin-icopathological parameters was analysed by SPSS 13.00 software.Results:EGFR gene amplification levels(69.2%)was positively related to the ratio of EGFR protein positive expression(7 1 .8%),the expression of EGFR,PCNA,LN and type IV collagen was posi-tively related to the clinical pathological parameters(P<0.05).There was a positive correlation between EGFR and PCNA expression (P<0.05),a negative correlation between LN protein and type IV collagen protein expression(P<0.05).Conclusion:EGFR gene is amplified in SACC.EGFR,PCNA,LN and type IV collagen take part in the occurrence and development of SACC.
