Expression of Wnt-1 and β-catenin in cervical squamous cell carcinomas and relationship with metastasis
10.13315/j.cnki.cjcep.2014.09.008
- VernacularTitle:子宫颈鳞状细胞癌中Wnt-1和β-catenin的表达及其与转移的关系
- Author:
Airong CHEN
;
Weidong ZHAO
;
Shiwu WU
;
Zenong CHENG
- Publication Type:Journal Article
- Keywords:
cervical neoplasm;
Wnt-1;
β-catenin;
tumor metastasis;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):979-982
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of Wnt-1 and β-catenin protein in cervical squamous cell carcinomas ( CSCC) and their relationship with invasion and lymph node metastasis. Methods Expression of Wnt-1 and β-catenin protein were examined on immunohistochemistry containing 78 specimens of CSCC and 30 specimens of normal cervical tissues. Results The positive rates of Wnt-1 and β-catenin protein in normal cervical tissues were 20.0% and 10.0% respectively. The positive rates of Wnt-1 andβ-cate-nin protein in CSCC were 56.4%, and 74.4% respectively. There was a significant difference between the two groups (P<0.001). The positive rates of Wnt-1 andβ-catenin protein in 33 cases with lymph node metastasis of CSCC were 72.7% and 90.9% respective-ly. The positive rates of Wnt-1 andβ-catenin protein in 45 cases with no lymph node metastasis of CSCC were 44.4% and 62.2% re-spectively. The expression of Wnt-1 andβ-catenin protein was significantly related with grades of tumors and depth of invasion and FI-GO stages (P<0.05), and there was no significantly difference between the expression of Wnt-1 andβ-catenin protein and CSCC pa-tients age (P>0.05). Spearman analysis showed that the expression of Wnt-1 protein was positive related to the expression ofβ-cate-nin protein (rs =0.490, P<0.001). Conclusion The abnormal expression of Wnt-1 and β-catenin may be involved in initiation, development, invasion, and metastasis of CSCC, and it is suggested that Wnt-1 and β-catenin be considered as potential markers for invasion, metastasis, and prognosis.
