Expression and association of IMP3 and MVD in squamous carcinoma of the cervix
10.13315/j.cnki.cjcep.2014.09.012
- VernacularTitle:子宫颈鳞状细胞癌中IMP3表达与MVD的相关性分析
- Author:
Yajun ZHANG
;
Xin JIANG
;
Yue JIANG
;
Mingda CHENG
;
Ming LI
- Publication Type:Journal Article
- Keywords:
cervix neoplasm;
squamous carcinoma;
cervical intraepithelial neoplasia;
insulin-like growth factor-IImRNA-binding pro-tein 3;
microvessel density
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):996-999
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of insulin-like growth factorIImRNA binding protein 3 ( IMP3 ) and microvessel density (MVD) in squamous carcinoma of the cervix (SCC) and analysis their relationship in SCC. Methods The expression of IMP3 and MVD was examined by immunohistochemistry SP method in normal cervical epithelium ( NCE) , low-grade cervical intraepi-thelial neoplasia (CIN-L), high-grade cervical intraepithelial neoplasia (CIN-H) and SCC. Results (1)The positive expression rates of IMP3 in NCE, CIN-L, CIN-H, SCC tissues were 0(0/15), 0(0/11), 37.5%(9/24) and 86.0%(43/50), the difference was statistically significant (x 2 =53.345, P=0.000). IMP3 expression was significant difference among NCE and CIN-H, SCC (P<0.008 3), and that was also among SCC and CIN-L, CIN-H (P<0.008 3). (2)The MVD count was increased with the development of cervical squamous lesion, there was significant difference among those groups (F=145.968, P<0.01), and the difference was al-so statistically significant between every two groups (P<0.05). The positive expression of IMP3 and MVD count in 50 cases of SCC tissues showed statistical difference in different pathologic grade, lymph node metastasis, and depth of tumor invasion groups ( P<0.05), but didn't in different patients’age groups (P>0.05). And the positive expression of IMP3 was closely related with MVD count in SCC tissues (rs =0.323, P<0.05). Conclusion IMP3 plays an important role in the occurrence, infiltration and metasta-sis of SCC, and the abnormal expression of IMP3 may relate with the angiogenesis of tumors.
