Quantitative evaluating the heritability explained by known susceptibility variants of schizophrenia
10.3936/j.issn.1002-0152.2014.08.001
- VernacularTitle:定量计算已知易感变异对精神分裂症遗传度的解释度
- Author:
Kang LI
;
Ruihuan XU
;
Hongde ZHANG
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Genome-wide association study;
Single nucleotide polymorphism
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(8):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the heritability explanation degree of schizophrenia by all known susceptibility variants in schizophrenia. Methods The GWAS catalog of National Human Genome Research Institute (NHGRI) was queried to retrieve all the susceptible gene variations of schizophrenia. Sixty-two variants with risk allele frequency and odds ratio (OR ) were selected from 347 susceptible gene variants of schizophrenia. The heritability explanation degree of each susceptibility variants was calculated using the multifactorial liability threshold model. Results The total heritabili-ty explanation degree of schizophrenia by 62 known susceptible variants was 25.66%. In contrast, 74.34%of heritability, which could not be explained by known susceptibility variants, were then defined as the missing heritability of schizophre-nia. Conclusions The results demonstrate that the heritability explanation degree of schizophrenia by all known suscepti-bility variants in schizophrenia is low, indicating that there may be many unknown schizophrenia molecular genetic mech-anisms need to be further clarified.
