The characteristics of PET scan in the Alzheimer disease and vascular dementia
10.3936/j.issn.1002-0152.2014.08.005
- VernacularTitle:阿尔茨海默病与血管性痴呆的18F-FDG PET显像特点
- Author:
Shuwen XU
;
Guangsheng GAO
;
Shuyi LUO
;
Shaotong XIANG
;
Hao XIAO
;
Fangfang HU
;
Weiping CHEN
;
Yuedong HUANG
- Publication Type:Journal Article
- Keywords:
PET 18F-FDG;
Alzheimer disease;
Vascular dementia
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(8):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate early and differential diagnosis of Alzheimer disease and vascular dementia (VD)using FDG-PET scan. Methods Clinical data was collected from AD,VD and normal control(NC). 18F-2-fluo-ro-deoxy-D-glucose(18F-FDG)PET scan was conducted to detect the cerebral FDG metabolism. The average standard uptake value (SUV) of cerebral regions was expressed as semiquantitative index relative to ipsilateral cerebellum. Re-sults There were no differences in age and the mean total scores of the mini mental status examination (MMSE) between patients with VD and those with AD.The AD group showed that the SUV was significantly decreased in the right frontal, parietal,temporal lobe,hippocampus,temporo-parietal junction,and bilateral posterior cingulate cortex compared to the VD and in the bilateral posterior cingulate cortex,temporo-parietal junction,frontal and temporal lobe comparing to the NC(P≤0.01). SUV was significantly increased in the right parietal,posterior cingulate cortex and hippocampus whereas was significantly decreased in the left frontal lobe,temporo-parietal junction and thalamus in the VD compared with NC group(P≤0.01). Conclusion AD patients have typical features of 18F-FDG PET which may be helpful for the diagnosis of AD in the early stage.
