Protective Effect of Nicorandil on Myocardial Injury and Recurrent Angina after Percutaneous Coronary Intervention
10.3969/j.issn.0253-9896.2014.10.019
- VernacularTitle:尼可地尔对PCI相关心肌损伤及再发心绞痛症状的影响
- Author:
Shuhan YANG
;
Cheng WANG
;
Yanbin LIU
;
Minglei HAN
- Publication Type:Journal Article
- Keywords:
angioplasty,transluminal,percutaneous coronary;
angina,unstable;
creatine kinase,MB form;
troponin I;
Nicorandil
- From:
Tianjin Medical Journal
2014;(10):1026-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect of pre-operation administration of nicorandil on myocardial injury and recurrent angina in patients with unstable angina pectoris who underwent percutaneous coronary intervention (PCI). Methods A total of 91 patients with unstable angina pectoris were admitted for PCI and randomly divided into 2 groups who either received nicorandil(5 mg tid)or not for 7 days prior to the procedure and routine dose of nicorandil (5mg tid) after it. The concentrations of creatine kinase MB (CK-MB) and cardiac troponin I(cTnI) were compared between two groups before PCI and 6 hours, 18 hours and 24 hours after PCI;Recurent angina and major adverse cardiac events,includ-ing death,re-infarction and stroke at 6 months after the procedure were also chased and compared. Results In total, 75 pa-tients who were successfully undergone elective PC1 were finally enrolled,among whom 37 cases were in nicorandil group and 38 cases were in routine group. Post-procedural levels of CK-MB and cTnI significantly reduced in the nicorandil group between 6~24 h (P<0.05) compared those in routine group.At 6 months follow-up,symptoms of recurrent angina after PCI were significantly relieved in the nicorandil group compared with that in routine group (P < 0.05).Conclusion nicorandil can limit the PCI-induced myocardial injury and relieve the symptoms of recurrent angina after PCI in patients with unstable angina.
