The effects of nano-chitosan/bone morphogenetic protein gel on the repair of mandibular defect

VernacularTitle:纳米壳聚糖骨形成蛋白水凝胶修复下颌骨缺损实验研究
Author: Yuyang CHEN ; Fuqiang XIE ; Yun ZHANG ; Xin WANG ; Jian SUN
Publication Type:Journal Article
Keywords: Mandibular defect; Nano-chitosan; Gel; Bone morphogenetic protein-2(BMP-2)
From: Journal of Practical Stomatology 2014;(5):624-628
CountryChina
Language:Chinese
Abstract: Objective:To investigate the effects of Nano-chitosan rhBMP-2 Gel(NCS/BMP-2 Gel)on the repair of mandibular de-fect.Methods:NCS/BMP-2 Gel and NCS Gel were prepared and respectively injected into the subcutaneous space on both sides of dorsum of 9 rats.3 rats were respectively sacrificed 10,20 and 30 d after injection.The subcutaneous nodules were histologicaly ex-amined.Mandibular defect was made in 54 SD rats and the rats were divided randomly and into 3 groups(n=18):NCS/BMP-2 Gel was implanted into the defects in group 1,NCS Gel in group 2,no injection in group 3.Animals were sacrificed 3,6 and 9 weeks after transplantation.X-ray examination,pathologic observation were conducted.Results:Subcutaneous nodules were found in both sides of the rat dorsum.The residual mandibular defect area in study group 1 was apparently smaller than that in group 2 and 3(P<0.05). More new bone formation was observed in the gel injected area in group 1 than in group 2 and 3.Conclusion:Nano-CS/BMP-2 Gel is biocompatible and can accelerate the healing of mandibular defect.