Expression of IFN-γ,IL-4 and IL-1 7 proteins in peripheral blood of patients with oral lichen planus
10.3969/j.issn.1001-3733.2014.05.025
- VernacularTitle:口腔扁平苔藓患者外周血IFN-γ、IL-4和IL-17的表达及意义
- Author:
Qiong CHEN
;
Yang CAI
;
Qiujing FENG
- Publication Type:Journal Article
- Keywords:
Oral lichen planus;
T lymphocyte;
Interferon-γ;
Interleukin-4;
Interleukin-17
- From:
Journal of Practical Stomatology
2014;(5):698-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of IFN-γ,IL-4 and IL-17 in peripheral blood of patients with oral lichen planus(OLP). Methods:The level of IFN-γ,IL-4 and IL-17 in peripheral blood were detected by ELISA in 60 OLP patients(including 30 erosive ca-ses and 30 non-erosive cases)and 25 healthy volunteers(controls).Data were statistically analyzed by SPSS 13.0.Results:(1 )The level of IFN-γin serum of patients with non-erosive OLP and erosive OLP were significantly lower than that in the controls(P<0.01);while the level of IL-4 in the patients were significantly higher than that in the controls(P<0.01),and the IFN-γ/IL-4 ratio in non-ero-sive OLP and erosive groups were significantly lower than that in the control group(P<0.01);(2)The level of IL-17 in erosive OLP pa-tients was significantly higher than that in the controls(P<0.05),while no statistical difference was seen between non-erosive OLP group and the control group(P>0.05).Conclusion:The down-regulated level of IFN-γand up-regulated level of IL-4,which result in the decrease of IFN-γ/IL-4 ratio,might be one of the immune etiological factors of OLP,while the up-regulated level of IL-17 protein in OLP may be mainly related with the inflammatory processes of OLP.
