Clinicopathological features of multilocular cystic renal cell carcinoma:a series of 32 cases
10.13315/j.cnki.cjcep.2014.09.014
- VernacularTitle:多房囊性肾细胞癌32例临床病理分析
- Author:
Suying WANG
;
Huizhi ZHANG
;
Dalong CAO
;
Xiaoqun YANG
;
Hualei GAN
;
Chaofu WANG
- Publication Type:Journal Article
- Keywords:
renal neoplasm;
multilocular cystic renal cell carcinoma;
pathological features;
differential diagnosis;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):1004-1006
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features of multilocular cystic renal cell carcinoma ( MCRCC) , and to im-prove the understanding of this disease. Methods Thirty-two of MCRCC were studied by clinic data, pathological features and immu-nophenotype. All the thirty-two cases were followed up. Results In this study, thirty-two patients were diagnosed as MCRCC with a male-to-female ratio of 2.2 : 1, thirteen of whom had the tumor in the left kidney, eighteen in the right kidney, another in the double kidneys. The mean of tumor diameter was 4.6 cm (1.0~8.0 cm). Eleven patients underwent radical nephrectomy while the other 21 patients received nephron sparing surgery. Microscopically, all the cases were multiocular, lined in the cyst wall by a single layer of tumor cells with the clear or pale cytoplasm and Fuhrman grade 1 nuclei. Occasionally, the lining consisted of several layers of tumor cells or a few small papillae were present. The linings of the cyst wall were rich in thin-wall blood vessels. Immunohistochemically, the tumor cells were positive for CK(32/32), CK7(25/32), EMA(32/32), CD10(23/32) and vimentin(20/32), while negative for CD68. Conclusions MCRCC is characteristic by low grade nuclei, lacking solid nodules, and in the cyst wall, and has a favourable prognosis. The rich in thin-wall blood vessels and the lining cells with the clear or pale cytoplasm are diagnosis clues.
