Clinical characteristics and Oxford classification of IgA nephropathy patients with hyperuri-cemia
10.13315/j.cnki.cjcep.2014.09.015
- VernacularTitle:IgA肾病高尿酸血症与牛津病理分型及临床特征
- Author:
Wei ZHANG
;
Yonggui WU
;
Weilong LIANG
;
Xiao JIANG
;
Zhe WANG
;
Xingxin XU
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
hyperuricacidemia;
kidney pathology;
Oxford classification
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):1007-1010
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinical characteristics and Oxford classification of IgA nephropathy patients with hyperurice-mia. Methods 151 IgA nephropathy patients confirmed by renal biopsy in 2013 were analyzed retrospectively. The patients were di-vided into the two groups:IgA nephropathy patients with or without hyperuricemia. Morphological changes were evaluated with Oxford classification scoring system and Lee’s grades. A comparative analysis of clinical manifestations and pathological injuries was performed between the two groups. Results Incidence of hyperuricemia in IgA nephropathy patients was 48. 3% and was more common in young men. Hypertension was associated with hyperuricemia. Oxford classification of IgA nephropathy patients with hyperuricemia was pre-dominant M1E0S1T0 and Lee’s grades presented with grade Ⅲ. The outstanding histopathologic features with higher plasma uric acid levels indicated higher tubulointerstitial chronicity, higher glomerular sclerosis ratio, accompanied by a decline in glomerular filtration rate. There was no significant difference of vascular lesions. Conclusions The prevalence of hyperuricemia in IgA nephropathy pa-tients is high. Oxford classification shows IgA nephropathy with hyperuricemia are associated with more severe tubulointerstitial lesions and lower GFR.
