Hyalinizing trabecular tumours of thyroid:a clinicopathologial analysis of 6 cases
10.13315/j.cnki.cjcep.2014.09.020
- VernacularTitle:甲状腺透明变梁状肿瘤6例临床病理分析
- Author:
Liyan LIU
;
Sheng ZHANG
;
Yongjian LIU
;
Hong CHEN
;
Shijie CAI
;
Xiaoyun LIN
;
Yumei CHEN
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
hyalinizing trabecular tumour;
pathologic diagnosis;
differential diagnosis;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):1030-1033
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical pathological features and differential diagnoses and therapeutics of hyalinizing trabecular tumours ( HTT) of thyroid. Methods The clinical manifestations, high-frequency color doppler ultrasonography, histopathological and immunohistochemical features were analysed in six cases of HTT of thyroid. Related literatures were reviewed. Results On his-topathological examination, polygonal and elongated cells arranged in pattern of trabecular and organoid, with a clear perinucleolus ha-lo. Basement membrane-like material deposited intertrabeculae widespreadly. The tumour cells are completely filled with eosinophilic and granular material in their cytoplasm, nuclei with prominent grooves and pseudoinclusions. Immunohistochemically, the tumour cells were positive for TG, TTF-1 and CD56, CK19 and Galectin-3 interspersed expression. And all of them were negative for Calcito-nin, MC, CEA, Syn, CgA, Ki-67, p53 were lower expression. The differential diagnosis included solid variant of papillary carcinoma, medullary thyroid carcinoma and paraganglioma and so on. Conclusion HTT is an uncommon thyroid tumor, the majority of them be-have as benign neiplasms and that, correct pathologic diagnosis may play an important role in standard treatment and prognostic evalua-tion of HTT.
