Relationship between XPD Lys751Gln polymorphisms and the risk of adult acute leukemia

VernacularTitle:XPD Lys751Gln多态性与成年人急性白血病发病风险的关系研究
Author: Yun XIAO ; Kun WU ; Yongmei LIU
Publication Type:Journal Article
Keywords: Leukemia; Adult; XPD; Polymorphism
From: Journal of Leukemia & Lymphoma 2010;19(10):613-615
CountryChina
Language:Chinese
Abstract: Objective To detect the relationship between XPD Lys751Gln polymorphism and the risk of adult acute leukemia (AL). Methods 100 adult AL patients and 100 controls were chose as case and Lys751Gln were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) analysis in peripheral blood. Results The genotype frequency of Lys/Lys, Lys/Gln, Gln/Gln were 83 %, 16 %, 1% in case group and 90 %, 10 %, 0 in control group, respectively. The difference the two groups was no signficant difference (x2=1.44, P =0.49). No significantly increased risk for adult AL was observed for those carrying variant genotype with OR analysis (x2 = 2.10, P =0.15, OR =1.84; 95 % CI 0.80-4.25). Individuals with the variant genotype of XPD Lys751Gln might enhance the risk of adult AL (OR =2.77, 95 % CI 0.99-7.73). Conclusion XPD Lys751Gln polymorphism is found to have relationship with adult acute lymphocytic leukemia.