Comparison of in vitro Antibacterial Activity between Cefozopran and 3 Commonly Used Antibiotics
- VernacularTitle:注射用盐酸头孢唑兰与3种常用抗菌药物体外抗菌活性比较
- Author:
Hongxia ZHANG
;
Xiang WANG
;
Weishe LI
- Publication Type:Journal Article
- Keywords:
Cefozopran;
Antimicrobial agents;
In vitro;
Antibacterial activity
- From:
China Pharmacist
2014;(12):2162-2164
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the in vitro antibacterial effect of cefozopran on the clinical isolate bacteria to provide reference for its clinical use. Methods:An AGAR double dilution method was used to determine the in vitro antibacterial effect of cefozopran on 14 classes, 127 strains pathogenic bacteria isolated from the respiratory and urinary tract infections, and compared with that of 3 commonly used marketed antimicrobial agents. The parallel experiments were repeated for 3 times to observe the final results. Results: MIC50 of cefozopran against 7 kinds of clinical isolate G+ strains including Staphylococcus aureus, Pyogenic streptococcus, Streptococcus pneumoniae, Streptococcus, Methicillin-sensitive Staphylococcus aureus ( MSSA) and Methicillin-sensitive Staphylococcus epidermidis ( MSSE ) was within the range of 0. 125 ~ 1 μg·ml-1 and MIC90 was within the range of 0. 5 ~ 8 μg · ml-1 . Average MIC of cefozopran against Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Enterobacter aerogenes, Pseudomonas aeruginosa and Enterobacter cloacae was 0. 23,0. 21,0. 42,4. 74, 6. 31,8. 75 and 16. 35 μg ·ml-1 , respectively. Conclusion: Cefozopran shows obvious in vitro antibacterial effect on respiratory and urinary tract infection strains with significant antimicrobial activity in vitro.
