Study on Antifungal Activities of Zhexinmycin against Dermatophytes in vitro
- VernacularTitle:浙新霉素对皮肤癣菌的体外抗真菌活性研究
- Author:
Meiling ZHANG
;
Yaping BAO
;
Bo YANG
;
Fanzhi KONG
- Publication Type:Journal Article
- Keywords:
Zhexinmycin;
Dermatophytes;
In vitro antifungal activity
- From:
China Pharmacist
2014;(12):2001-2003
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate in vitro antifungal activities of zhexinmycin against dermatophytes. Methods: The minimum in-hibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of zhexinmycin against 7 strains of dermatophytes were determined by using broth microdilution method according to CLSI M-38A. Results:The MIC of zhexinmycin against dermatophytes was within the range of 0. 125-2. 000μg·ml-1 . The MFC was within the range of 0. 250-4. 000μg·ml-1 . Conclusion:Zhexinmycin shows strong in vitro antifungal effect on multiple fungi such as Epidermophyton floccosum, Trichophyton rubrum, Trichophyton violaceum, Mi-crosporum canis, Trichophyton mentagrophytes, Trichophyton tonsurans and Microsporum gypseum.
