Studies on Bio-adhesive Force and Dissolution of 5-Fluorouracil HP-β-CD Inclusion Complex Thermo-sensi-tive Gels
- VernacularTitle:氟尿嘧啶-羟丙基-β-环糊精包合物温敏凝胶生物黏附力及溶出度研究
- Author:
Lulu WANG
;
Shaohua CHEN
;
Li XIANG
;
Xiuli ZHANG
;
Wensheng ZHENG
- Publication Type:Journal Article
- Keywords:
Fluorouracil;
HP-β-CD inclusion complex;
Thermo-sensitive gels;
Adhesion;
Dissolution
- From:
China Pharmacist
2014;(12):2040-2042
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of various bio-adhesive polymers on bio-adhesive characteristics and release rate of 5-fluorouracil HP-β-CD inclusion complex thermo-sensitive gels. Methods: Bio-adhesive polymer, such as hydroxypropylmethylcellu-lose ( HPMC) , sodium alginate ( SA) , sodium hyaluronat ( HA) ,carbopol and polycarbophil was respectively used to prepare the ther-mo-sensitive gels, and the bio-adhesive force was studied. The phosphate buffer (pH 7. 2) was used and the drug release characteris-tics were studied using dialysis technique. Results: The bio-adhesive force of the gels with 0. 2% polycarbophil was 32. 3 g·ml-1 , and the drug release time was prolonged to 8 h. There was no obvious difference in the dissolution among the gels with the various bio-adhesive polymers. Conclusion:Using 0. 2% polycarbophil as the bio-adhesive polymer, 5-fluorouracil HP-β-CD inclusion complex thermo-sensitive gels show good bio-adhesive force and prolonged drug release characteristics.
