Study on Quality Standard for Tangzhixiao Capsules
- VernacularTitle:糖脂消胶囊质量标准的建立
- Author:
Zhiqiang PU
;
Kai JU
;
Hua CHEN
;
Weihua JIN
;
Ming ZHANG
;
Mingqiang WANG
- Publication Type:Journal Article
- Keywords:
Tangzhixiao capsules;
TLC;
HPLC;
Salvianolic acid B
- From:
China Pharmacist
2014;(12):2136-2138
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the quality standard for Tangzhixiao capsules. Methods: The qualitative identification of Salvia miltiorrhiza,Atractylodes and Hawthorn was detected by TLC, and the quantitative determination of salvianolic acid B was determined by HPLC. The HPLC determination was performed on a YMC-Triart C18 (250 mm × 4. 6 mm, 5μm ) column with the mobile phase consisted of acetonitrile-0. 1% phosphoric acid (24∶ 76) at the flow rate of 1. 0 ml·min-1 , the column temperature was 30℃ and the detection wavelength was set at 286 nm. Results: The TLC spots were fairly clear, and the negative samples showed no interference. The concentration of salvianolic acid B within the range of 0. 012-0. 120 mg·ml -1 was linear with peak area(r = 0. 999 5), the average recovery was 100. 06% and RSD was 0. 83%(n = 6). Conclusion: The method is accurate, reliable and reproducible, which can be used in the quality control of Tangzhixiao capsules.
