Therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease
10.3760/cma.j.issn.1673-4246.2014.12.010
- VernacularTitle:抗病毒口服液联合利巴韦林气雾剂治疗手足口病的临床研究
- Author:
Xiuchun YE
- Publication Type:Journal Article
- Keywords:
Hand,foot and mouth disease;
Ribavirin;
Kangbingdu oral liquid;
Child
- From:
International Journal of Traditional Chinese Medicine
2014;(12):1089-1091
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease (HFMD). Methods A total of 135 HFMD children were enrolled and assigned to receive ribavirin aerosol alone (ontrol group, 67 patients) or ribavirin aerosol plus Kangbingdu oral liquid group (treatment group, 68 patients) for 7 days. Therapeutic effect was evaluated as the time to fever resolution, subsidence of skin rash and oral ulcers. All throat swab samples were tested using a fluorescence quantitative RT-PCR assay for panenteroviruses, enterovirus 71(EV71)and Coxsackievirus A16 (CA16). Results The time to fever resolution(2.51±0.42 d vs. 3.92±0.61 d;t=15.621, P<0.01), subsidence of skin rash(4.22±1.34 d vs. 6.33±1.41 d;t=8.914, P<0.01)and oral ulcers(3.01±0.32 d vs. 4.52±1.21 d;t=9.880, P<0.01)in the treatment group were significantly shorter than those in the control group. The healing rate in the treatment group were significantly higher than that in the control group(88.2%vs. 44.8%;χ2=26.761, P<0.01), and total effective rate was no different in treatment and control groups(94.1%vs. 83.6%;χ2=2.801, P=0.094). The rates of conversion from positive to negative for panenteroviruses(90.9% vs. 52.6%;χ2=13.331, P<0.01)and EV71(83.3%vs. 52.4%;χ2=4.307, P=0.038)in the treatment group were significantly higher than those in the control group, and the rate of conversion from positive to negative for CA16 was no different in treatment and control groups(93.3%vs. 81.8%;χ2=0.082, P=0.774). Conclusion Kangbingdu oral liquid in combination with ribavirin aerosol may improve the rate of conversion from positive to negative for enteroviruses, reduced the time to fever resolution, subsidence of skin rash and oral ulcers in HFMD children.
