Study on Quality Standard for Isatidis Folium Dispensing Granules
- VernacularTitle:大青叶配方颗粒质量标准研究
- Author:
Wei GONG
;
Qinghua ZHAO
;
Mei ZHAO
;
Xu SUN
;
Zhongliang LIU
;
Xingdong LI
;
Xinxin ZHANG
;
Kun ZHANG
- Publication Type:Journal Article
- Keywords:
Isatidis folium dispensing granules;
Quality standard;
TLC;
Extract;
HPLC;
Indirubin
- From:
China Pharmacist
2014;(12):2021-2023
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the quality standard for Isatidis folium dispensing granules. Methods:Indigo and indirubin in the granules were identified by TLC. The extract content was determined by a hot dipping method for the determination of alcohol-solu-ble extract. The content of indirubin was determined by HPLC. Results:The spots in TLC were clear and well-separated. The extrac-tion limit no less than 12. 0% was preliminarily drawn up. Indirubin showed a good linear relationship within the range of 0. 50-8. 04μg·ml-1(r=0. 999 9) with the average recovery of 99. 41%(RSD=1. 21%, n=9). The content limit no less than 50. 0 μg per pack was preliminarily drawn up for indirubin. Conclusion: The method is easy-operated and accurate with good specificity for the quality control of Isatidis folium dispensing granules.
