Research progress of pharmacokinetic study on paeoniflorin
10.3969/j.issn.1001-1978.2014.12.006
- VernacularTitle:芍药苷药物代谢动力学研究进展
- Author:
Chun WANG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
paeoniflorin;
total glucosides of paeony;
absorption;
distribution;
metabolism;
excretion
- From:
Chinese Pharmacological Bulletin
2014;(12):1646-1650
- CountryChina
- Language:Chinese
-
Abstract:
Total glucosides of paeony (TGP)is used to treat rheumatoid arthritis(RA)as the first immunoregulatory drug in clinic.The efficacy of TGP in treating RA patients is definite, which is accompanied with mild adverse reaction and slow effects simultaneously.Paeoniflorin (Pae ),the main constituents of TGP,has a bioavailability of 3% ~4%,which may be served as the main reason for its slow effects.Therefore,in this paper,the pharmacokinetics of Pae as well as its influencing factors were re-viewed on basis of pulished papers.In addition,some problems about Pae were also discussed.
