Rho Kinase Activity Predicts Left Ventricular Remodeling in Patients With Acute ST-segment Elevation Myocardial Infarction
10.3969/j.issn.1000-3614.2014.11.003
- VernacularTitle:Rho激酶活性对于ST段抬高型急性心肌梗死患者左心室重构的预测作用﹡
- Author:
Cuimei ZHAO
;
Li LI
;
Luying PENG
;
Jinfa JIANG
;
Wenjun XU
;
Wenlin MA
;
Jiahong XU
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Rho kinase;
Left ventricular function
- From:
Chinese Circulation Journal
2014;(11):867-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the predictive value of an early inflammatory response factor, Rho kinase activity for left ventricle remodeling (LVR) in patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods: A total of 120 acute STEMI patients treated in our hospital from 2010-10 to 2013-06 were studied, all patients were ifrst time received primary percutaneous coronary intervention (PCI) with stent implantation. Rho kinase activity and B-type natriuretic peptide (BNP) were measured before PCI, echocardiography was conducted at 24 hours and 12 months after STEMI respectively to clarify LVR diagnosis. The patients were divided into 2 groups as LVR group, n=97 and Non-LVR group, n=23, the above indexes were compared between 2 groups.
Results: The level of Rho kinase was higher in LVR group than that in Non-LVR group, P<0.001, after adjustment, Rho kinase was the independent predictor for LVR (OR 3.36, 95%CI 2.01–5.78, P<0.001). The ROC of Rho kinase was 0.88 (95%CI 0.82–0.94) and the ROC of BNP was 0.54 (95%CI 0.41–0.70).
Conclusion: High Rho kinase activity could predict LVR in acute STEMI patients with primary PCI and stent implantation.
