Analysis of Contrast Media Iodixanol-induced Delayed Adverse Reaction With the Risk Factors in General Clinical Practice
10.3969/j.issn.1000-3614.2014.11.012
- VernacularTitle:临床应用碘对比剂碘克沙醇致迟发药物不良反应及危险因素分析
- Author:
Qiang MING
;
Yang SU
;
Weijing LIU
;
Lei HOU
;
Jianying SHEN
;
Wenliang CHE
;
Xiankai LI
;
Yi ZHANG
;
Yawei XU
- Publication Type:Journal Article
- Keywords:
Contrast media;
Iodixanol;
Adverse reaction;
Risk factor
- From:
Chinese Circulation Journal
2014;(11):903-906
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the incidence of coutrast media iodixanol-induced delayed adverse reaction with the risk factors in general clinical practice.
Methods: A total of 20,185 patients with contrast iodixanol were recruited from 95 medical centers in China. The risk factors for adverse drug reaction as hypertension, asthma, previous contrast reaction were assessed;the administrative processes as route, injection manner, lfow rate of injection, prior heating of iodixanol were monitored and the demographic information was documented. The immediate adverse reaction within 1 hour of media administration and the delayed adverse reaction from 1 hour to 7 days after administration were recorded. The risk factors for iodixanol-induced delayed adverse reaction were studied by singlevariate and multivariate logistic regression analysis.
Results: The overall iodixanol-induced adverse reaction rate was 1.52%, of which the immediate reaction was 0.58%and delayed reaction was 0.97%. The major delayed reaction was mild and it mostly happened in skin (0.68%) including rash, pruritus and urticaria. Multivariate logistic regression analysis revealed that male gender (OR=0.71, P=0.036), age (OR=0.82, P=0.001), route of administration (OR=0.21, P<0.001), prior heating of iodixanol (OR=1.44, P=0.036), lfow rate of injection (OR=1.28, P=0.001) and previous contrast reaction (OR=16.04, P<0.001) were the independent risk factors for delayed adverse reactions.
