Effect of insulin treatment on cognitive function of patients with Alzheimer′s disease and type 2 diabetes mellitus

VernacularTitle:胰岛素治疗对阿尔茨海默病合并2型糖尿病患者认知功能的影响
Author: Cui ZHAO ; Wei LI ; Lu WANG ; Guoyu WANG ; Junjie CAO ; Miao WANG
Publication Type:Journal Article
Keywords: Alzheimer′s disease; diabetes mellitus,type 2; insulin; cognitive impairment
From: Military Medical Sciences 2014;(11):890-892
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effect of insulin combined with oral hypoglycemic agents on cognitive function of patients with Alzheimer′s disease(AD) and diabetes mellitus(DM).Methods We retrospectively reviewed 135 cases of AD patients with type2 DM(T2DM) admitted to our hospital between March 2011 and March 2013. According to drug use , they were randomly divided into two groups , oral hypoglycemic drug group ( group A, 65 cases ) and insulin combined with oral hypoglycemic drug group (group B,70 cases).After 12 months of follow-up, the Mini Mental State Examination (MMSE) score by Folstein et al and Clinical Global Impression Scale (CGI) were used to assess their cognitive function .Results After 12 months of treatment , the MMSE score decreased significantly in group A ( P=0.000), but not in group B(P=0.281).Also, CGI-C scores showed significant deterioration for all domains after 12 months in group A vs group B(P=0.001).Conclusion Insulin therapy can effectively slow down the decline of cognitive function in patients with AD .