Expression and clinical significance of FGF-19 in hepatocellular carcinoma
10.7644/j.issn.1674-9960.2014.11.013
- VernacularTitle:成纤维细胞生长因子19（FGF-19）在肝细胞癌组织中的表达及临床意义
- Author:
Lu SHI
;
Shichang CUI
;
Lin GONG
;
Weisheng YUAN
;
Luo XU
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
FGF-19;
prognosis
- From:
Military Medical Sciences
2014;(11):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To analyze the expression of fibroblast growth factor-19(FGF-19) in hepatocellular carcinoma ( HCC) and adjacent tissues , and to investigate its clinical significance .Methods A total of 209 HCC patients who had undergone radical resection operations at Hospital 401 between January 2003 and December 2009 were chosen as samples . Immunohistochemistry method was employed to examine the expression level of FGF-19 in HCC and adjacent tissues .The relationship between FGF-19 protein expressions and clinicopathological features was analyzed by the chi -square test or Fisher exact probability .A survival curve was drawn using the Kaplan-Meier method and the Cox model was used to analyze factors that influenced survival .Results The rate of high expression of FGF-19 was 66.1% (138/209) in HCC, which was significantly higher than 46.9%(98/209) in adjacent tissues (P<0.05).The high expression of FGF-19 was related to the tumor capsule and tumor boundary (P<0.05).The overall survival in high expression of FGF-19 group was signifi-cantly lower than that in low expression group (P<0.05).Conclusion FGF-19 plays an important role in the carcinogen-esis and development of HCC , and a high expression of FGF-19 might be closely related to survival time of postoperative patients.FGF-19 might be a potential prognosis prediction factor for HCC .
