Association of Nonalcoholic Fatty Liver Disease with Hypertriglyceridaemic Wasit Phenotype Complicated with Type 2 Diabetes Mellitus
10.3969/j.issn.0253-9896.2014.12.019
- VernacularTitle:2型糖尿病合并高甘油三酯血症-腰围表型与非酒精性脂肪性肝病的相关性研究
- Author:
Weiguang DING
- Publication Type:Journal Article
- Keywords:
fatty liver;
diabetes mellitus,type 2;
nonalcoholic fatty liver disease;
hypertriglyceridaemic-waist phenotype
- From:
Tianjin Medical Journal
2014;(12):1219-1222
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the association of nonalcoholic fatty liver disease with hypertriglyceridaemic wasit phenotype complicated with type 2 diabetes mellitus. Methods Base on whether plasma triglycerides concentra? tion≥1.7 mmol/L or not, waist circumference≥90 cm or not in men or≥85 cm or not in women, patients with type 2 diabe?tes mellitus (n=804) were divided into four groups:normal waist circumference with normal triglycerides, normal waist cir?cumference with hypertriglyceridemia, abdominal obesity with normal triglycerides and hypertriglyceridemic-waist pheno?type (HTWC). The four groups’clinical data were recorded. Body mass index (BMI), homeostasis model assessment insulin resistance (HOMA-IR) and nonalcoholic fatty liver disease fibrosis score (NAFLDFS) were calculated and the results were compared among four groups. Results BMI, waist circumference, systolic blood pressure, diastolic blood pressure, HOMA-IR, alanine aminotransferase, aspartate aminotransferase , γ-glutamyltransferase, serum uric acid,NAFLDFS and the inci?dence of NAFLD were all higher in the HTWC group compared to non-HTWC group (P<0.01). Logistic regression analysis revealed that besides BMI,γ-glutamyltransferase and serum uric acid,HTWC was also a risk factor for NAFLD in patients with type 2 diabetes mellitus(OR=1.986,95%CI:1.006-3.921). Conclusion HTWC is a risk factor for NAFLD in patients with type 2 diabetes mellitus. Screening and diagnosis of HTWC is helpful for reducing the occurrence of NAFLD and can slow its progress through controlling and interfering metabolic disturbance.
