C-reactive protein and autoimmune diseases
10.3760/cma.j.issn.1009-9158.2014.11.018
- VernacularTitle:C反应蛋白与自身免疫性疾病
- Author:
Yang HAN
;
Tianpen CUI
;
Guilian CHENG
;
Binbin WAN
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Autoimmune diseases;
Apoptosis
- From:
Chinese Journal of Laboratory Medicine
2014;(11):876-878
- CountryChina
- Language:Chinese
-
Abstract:
Impaired clearance of apoptotic cells is important in the pathogenesis of autoimmune disease.C-reactive protein (CRP) is an acute phase protein that plays a major role in the regulation of the autoimmune and inflammatory response .CRP has a role in the clearance of bacteria and dying and altered cells through binding to phosphocholine and might also have more complex immunomodulatory functions . CRP function as opsonins for pathogens and dying and apoptotic cells through activation of the complement pathway and through binding to Fcγreceptors , and is associated with the clearance of apoptotic cells and nuclear antigen , thus becoming a protective molecule against pathogenic autoimmune responses in general . Measurement of serum CRP level is in widespread clinical use as a sensitive marker of inflammation and autoimmune disease , particularly in relation to the use of the CRP-based disease activity score in the evaluation of rheumatoid disease.
