The Changes of Serum Interleukin-37 Levels in Patients With Acute Coronary Syndrome
10.3969/j.issn.1000-3614.2014.11.004
- VernacularTitle:急性冠状动脉综合征患者白细胞介素-37水平变化的研究﹡
- Author:
Shaoyuan CHEN
;
Wuyi HE
;
Jian JIN
;
Hongcheng FANG
;
Peiyi XIE
;
Yousu SU
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Interleukin-37;
Inlfammation
- From:
Chinese Circulation Journal
2014;(11):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the serum interleukin-37 (IL-37) level changes in patients with acute coronary syndrome (ACS) and to explore the relationship between IL-37 and coronary atherosclerotic plaque.
Methods: Our research included 3 groups. ACS group, n=60, SAP (stable angina pectoris) group, n=30 and Control group, the subjects with normal coronary artery, n=15. The peripheral serum levels of IL-37 were examined by ELISA and the differences were compared among different groups.
Results: ① The serum levels of IL-37 at admission were as ACS group < SAP group < Control group, P<0.05.②Intervention could transitionally decrease IL-37 level in SAP group. With 4 weeks treatment, IL-37 levels were signiifcantly increased in both ACS group and SAP group than admission time, while they were still lower than Control group, P<0.05.③The serum level of IL-37 at admission was negatively related to IL-18 (r=-0.79, P<0.05), the ratio of IL-18/IL-37 were as ACS group>SAP group>Control group, P<0.05.④In ACS group, IL-37 level was negatively related to GRACE score (r=-0.71, P<0.05), the ratio of IL-18/IL-37 was positively related to GRACE score (r=0.73, P<0.05).⑤The diagnosis of ACS could be basically excluded if the patients with IL-37>77ug/L.
Conclusion: The serum IL-37 might be involved in the inlfammatory process in ACS patients, it could be expected as an index for ACS monitor and evaluation in clinical practice.
