Analysis of Platelet Inhibition Rate in Patients With Stable Angina Pectoris Combining Diabetes Mellitus
10.3969/j.issn.1000-3614.2014.11.005
- VernacularTitle:稳定性心绞痛合并糖尿病患者的血栓弹力图检测结果分析
- Author:
Long ZHANG
;
Haiyan QIAN
;
Dewei WU
;
Lei ZHENG
;
Li ZHANG
;
Mengyue YU
- Publication Type:Journal Article
- Keywords:
Stable angina pectoris;
Diabetes mellitus;
Thromboelastography;
Arachidonic acid inhibition rate;
Adenosine diphosphate inhibition rate
- From:
Chinese Circulation Journal
2014;(11):875-878
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the thromboelastography (TEG) outcomes in patients with stable angina pectoris (SAP) combining diabetes mellitus (DM).
Methods: A total of 360 SAP patients treated in our hospital by percutaneous coronary intervention (PCI) from 2012-01 to 2013-06 were randomized into 2 groups:SAP+DM group, n=109 and SAP-DM group, n=251. Routine clinical examination and TEG test were performed and compared between 2 groups.
Results: Compared with SAP-DM group, SAP+DM group showed the higher ratios of male gender, history of hypertension, hyperlipidemia and higher level of hs-CRP, all P<0.05. Single regression analysis indicated that DM was related to adenosine diphosphate (ADP) inhibition rate (r=0.977, P=0.0001), not related to arachidonic acid (AA) inhibition rate (r=0.245, P=0.069). Multi regression analysis presented that with controlled relevant factors, DM was still related to ADP inhibition rate (r=0.862, P=0.0001). The major TEG parameters as R value, K value,α-angle and MA value were obviously different between 2 groups, P<0.05, while the AA inhibition rate was similar, P=0.057. ADP inhibition rate was different between 2 groups, P=0.0001. The incidence of clopidogrel resistance was higher in SAP+DM group than that in SAP-DM group (34.7%vs 16.2%, P=0.001).
Conclusion: The SAP patients combining DM were at hyper-coagulation status with higher incidence of clopidogrel resistance, who needed intensive post-operative anti-platelet therapy.
