Effect of Valsartan on Inflammatory Cytokines in Patients With Hypertension Combining Paroxysmal Atrial Fibrillation
10.3969/j.issn.1000-3614.2014.11.008
- VernacularTitle:缬沙坦对高血压并阵发性心房颤动患者炎症因子的干预作用
- Author:
Jing LI
;
Yanqun ZHANG
;
Ruo HUANG
- Publication Type:Journal Article
- Keywords:
Valsartan;
Paroxysmal atrial ifbrillation;
High sensitive C-reactive protein;
Interleukin-6
- From:
Chinese Circulation Journal
2014;(11):888-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of valsartan on inflammatory cytokines in patients with hypertension combining paroxysmal atrial ifbrillation (PAF).
Methods:A total of 60 patients with hypertension combining PAF converted to sinus rhythm were studied and the patients were divided into 2 groups. Control group, the patients received felodipine and Valsartan group. n=30 in each group, all patients were treated for 6 months. In addition, there was a Normal group including 30 healthy subjects. The levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and left atrial diastolic diameter (LADd), the sinus rhythm maintenance rate were examined and compared before and after treatment among different groups.
Results: Compared with Normal group, the levels of hs-CRP, IL-6 and LADd were obviously higher in patients at both Control group and Valsartan group, all P<0.01. With 6 months of treatment, the levels of hs-CRP, IL-6 and LADd were decreased in both groups of patients than they were before, all P<0.01;compared with Control group, such effects were more obvious in Valsartan group, all P<0.01. The sinus rhythm maintenance rate in Valsartan group was signiifcantly higher than that in Control group, P<0.05.
Conclusion: Valsartan may inhibit inflammatory response and improve atrial structure remodeling, therefore better maintain the converted sinus rhythm in patients with hypertension combining PAF. The anti-inlfammatory effect of valsartan might be independent from its anti-hypertension effect.
